Uridine 2′-deoxy-5-ethynyl- cas:61135-33-9
| Catalogue Number | XD90589 |
| Product Name | Uridine, 2'-deoxy-5-ethynyl- |
| CAS | 61135-33-9 |
| Formulae hypotheticae | C11H12N2O5 |
| M. Pondus | 252.23 |
| Repono Details | -20°C |
| Tariff Code harmonized | 29349990 |
Product Specification
| Aspectus | Alba ad Aureum ad Green pulveris ad crystal |
| Assay | ≥99% |
Hoc studium perductus est ad inquirendum effectum proliferativum vegetabilis soy peptidum in cellularum caularum adultarum (ASCs) in absentia serum et earum agendi machinationes possibilis.Proliferatio humanorum adiposis texti mesenchymatis derivatae cellularum caulis mesenchymatis et funiculi sanguineo-deductum cellularum mesenchymalium (CB-MSCs) tractata cum soy peptidis inventa est ut signanter crescat in 3-(4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromidum et clic-iT 5-ethynyl-2'-deoxyuridine fluxum cytometriae primordium.Praeterea soy peptides gradatim ad phosphorylationem p44/42 MAPK (ERK), scopo mammalium rapamycini (mTOR), p70 S6 kinase, S6 interdum ribosomali (S6RP) et initiationis eukaryoticae factor 4E (eIF4E) in ADSCs.Praeterea analysis quantitatis cytokinorum ostendit productionem transformationis incrementi factoris-beta1 (TGF-β1), factoris incrementi endothelialis vascularis et interleukin-6 auctus insigniter in responsione ad curationem cum soy peptidis in utroque ADSCs et CB-MSCs.Similiter soy peptide inducta phosphorylatio ERK/mTOR/S6RP/eIF4E via impedita est responsio ad praetractationem cum PD98059, inhibitoris specifici ERK.Inhibitio autem TGF-β1 per PD98059 praetractationem et diminutionem consecutivam in ADSC multiplicationem revelatam TGF-β1 phosphorylationem mTOR/S6RP/eIF4E inducit.Collective, eventus huius studii indicant ERK-dependentem productionem TGF-β1 in munere maximo agere in soy peptide inducto multiplicationem ADSCs sub serum liberorum conditionibus.Copyright © 2012 Elsevier Inc. Omnia iura reservata.
