Uridine-5′-diphosphoglucuronic acidum trisodii salis CAS: 63700-19-6
| Catalogue Number | XD90382 |
| Product Name | Uridine-5'-diphosphoglucuronic acidum trisodii salis |
| CAS | 63700-19-6 |
| Formulae hypotheticae | C15H19N2O18P2Na3 |
| M. Pondus | 646.20 |
| Repono Details | < -4 °C |
Product Specification
| Assay | 99% |
| Aspectus | Pulvis albus |
Praesens studium intendit investigare influxum toxicitatis irinotecans per biotransformationem glucoaurantio-obtusin ad aurantio-obtusin.Administratio intraperitonealis (ip) 100 mg/kg aurantio-obtusin toxicitatem irinotecans insigniter auxit, sed administratio ip 100 mg/kg glucoaurantio-obtusin vim neglegendam erga toxicitatem irinotecans ostendit.Praeterea mechanismus explicatur per inhibitionem potentialem glucoaurantio-obtusin et aurantio-obtusin versus glucuronidationis metabolismi SN 38 determinans, quod maioris activum productum pro toxicitate irinotecan consideratum est.Eventus ostendit aurantio-obtusin inhibitionem fortem exhibitam competitive in inhibitionem versus glucuronidationem SN-38, sed neglegendam inhibitionem potentialem glucoaurantio-obtusin versus SN-38 glucuronidationis observatum est.Hi eventus demonstraverunt biotransformationem glucoaurantio-obtusin versus aurantio-obtusin augeri toxicitatem irinotecan per inhibitionem glucuronidationis SN-38 auctam.
