Phosphatase, alkaline CAS: 9001-78-9 alba, grisea alba vel persicus crystallus vel pulvis monoclinicus
| Catalogue Number | XD90379 |
| Product Name | Phosphatase, alkaline |
| CAS | 9001-78-9 |
| Formulae hypotheticae | C21H36N8O6 |
| M. Pondus | 496.57 |
| Repono Details | 2 ad 8 °C |
| Tariff Code harmonized | 35079090 |
Product Specification
| Assay | 99% |
| Aspectus | album, griseo album vel persici monoclinic crystal vel pulveris |
Etsi fluoride notum est ad os formationem incitare, machinae subiectae plene non intelleguntur.Recentes studia viam Wnt/β-catenin implicaverunt ut maiorem cascades in osse biologiae significantem.Studia nostra priora probabilia illustraverunt partes canonicae Wnt iter in osse formationis fluoride-expositae mures inclusi, sed mechanismus obscurum manet.Praesens studium implicationem Wnt/β-catenin significans in differentiatione osteoblasticae fluoride-inducta.Utens prima ratiuncula osteoblastarum, demonstravimus fluoride signanter promoveri osteoblastas proliferatione et phosphate alcalino (ALP) expressio necnon variantia expressionis gradus differentiationis ossis venalicium, in specie I collagen (COL1A1), ALP et osteonectin.Praeterea phosphorylationes fluoride inductae in serie 473 ex Akt et serina 9 glycogenis synthasis kinasi-3β (GSK3β), quae in inhibitione GSK-3β consecuta est, ac deinde nuclei cumulus β-catenin, ut patet per maculas occidentales et immunofluorescentiae analysis .Praeterea, fluoride etiam expressum Wnt-targeted e gene runt transcriptionis relatae factor 2 (Runx2).Potius effectus positivus fluoride in ALP activitatem et mRNA expressionum COL1A1, ALP, osteonectionum et Runx2 a DKK-1, obstructore receptoris Wnt/β-catenin abolita est.Simul sumptae, hae inventiones suggerunt fluoride differentiam osteoblasticam per Akt- et GSK-3β dependens activationem Wnt/β-catenin significans iter in prima rat osteoblastis significans.Inventiones nostras novas pervestigationes praebent in mechanismos actionis fluoride in osteoblastogenesis.
