Guanosine cas: 118-00-3
| Catalogue Number | XD90757 |
| Product Name | Guanosine |
| CAS | 118-00-3 |
| Formulae hypotheticae | C10H13N5O5 |
| M. Pondus | 283.24 |
| Repono Details | Ambiens |
| Tariff Code harmonized | 29349990 |
Product Specification
| Aspectus | Alba ad off-album crystallinum pulveris |
| Assay | 99% min |
| Metalla gravis | <10ppm |
| AS | <1ppm |
| Residere in Ignition | <0.1% |
Plures analoga guanosina, id est acyclovir (et ejus oralis valaciclovir), penciclovir (in forma prodrug orali, famciclovir) et ganciclovir, late pro herpesviri curatione adhibita sunt. 2 (HSV-2), virus varicella-zoster (VZV) et / vel cytomegalovirus humanus (HCMV)] contagio.Annis, complura analoga guanosina nova aucta sunt, inter derivationes 3-membratae cyclopropylmethyl et -methenyl (A-5021 et synguanol) ac 6-membrorum D- et L-cyclohexenyl derivatorum.Actio acyclici/carbocyclicae analogorum guanosinorum contra amplum virus spectrum determinatum est, incluso HSV-1, HSV-2, VZV, HCMV, ac etiam generis humani herpesvirorum 6 (HHV-6), typus 7 (HHV-. 7) et typus 8 (HHV-8), et hepatitis B virus (HBV).Nova analoga guanosina (id est A-5021 et D- et L-cyclohexenyl G) inventa sunt imprimis activa contra virus illa (HSV-1, HSV-2, VZV) quae encode pro thymidine kinasi specifici (TK), suggerentes eorum actio antiviralis (saltem ex parte) a phosphorylatione a viro inducta TK dependet.Operatio antiviralis notata etiam est cum A-5021 contra HHV-6, et cum D- et L-cyclohexenyl G contra HCMV et HBV.Actio antiviralis analogorum nuclei acyclici/carbocyclici nucleosidi notabiliter potentiari potuit ab acido mycophenolico, potens inhibitor dehydrogenasium 5'-monophosphatarum inosinae.Nova analoga carbocyclica guanosina (ie A-5021 et D- et L-cyclohexenyl G) magna promissione tenent, non solum ut agentes antivirales pro curatione infectionis herpesviri, sed etiam agentia antitumoris pro therapia gene therapia/chemotherapy cancri coniuncta; dummodo (part of) cellulae tuberculum a viralibus (HSV-1, VZV) TK gene.
