Cytidine-5′-triphosphate (CTP), disodium salis CAS:652154-13-7
| Catalogue Number | XD90551 |
| Product Name | Cytidine-5'-triphosphate (CTP), disodium salis |
| CAS | 652154-13-7 |
| Formulae hypotheticae | C9H14N3Na2O14P3 |
| M. Pondus | 527.12 |
| Repono Details | 2 ad 8 °C |
Product Specification
| Aspectus | Pulvis albus |
| Assay | 99% |
CTP: phosphocholine cytidylyltransferasis α (CCTα) est enzyme nuclei quod catalysem gradatim limitans in CDP-choline via synthesis phosphatidylcholine (PC) est.Lipida activatio CCTα consequitur in translocatione ad involucrum nuclei et expansionem membranae intranuclearis reticulum nucleoplasmicum (NR) per mechanismum membranae deformationis involventem.Laminae nuclei requiruntur etiam ad stabilitatem et multiplicationem ipsius NR, sed utrum haec unica structura, an lamina nuclearis in genere, pro PC synthesi requiratur ignoratur.Ad hanc relationem examinandam, lamina nuclearis a RNAi levata est vel ab expressione progeria progeria Hutchinson-Gifford (HGPS) mutant lamin A (progerin), et effectus metabolismi in CCTα et cholini enucleatus est.siRNA-mediata silentium lamin A/C vel lamin B1 in CHO cellulis minuendi NR in synthesi PC nullum effectum habuit, dum duplicatum colaphum non-specialis iter inhibuit.Confirmans suam partes minores in PC synthesin, solum 10% phosphotransferasis obiter expressas in NR deprehensum est.In cellulis CHO, CCT a nucleoplasmicus et co-locatus cum GFP-progerin in plicarum nuclei et invaginationibus;attamen, HGPS fibroblastae abnormalem distributionem CCTα in cytoplasmo et involucro nucleari ostendi, quae cum 2-duplici reductione in synthesi PC comitata est.Invita localizationis mutata, experimenta choline-labellantes demonstraverunt actionem CCT non integra esse, et inhibitio synthesis PC reducta ad activitatem hemicholini-sensitivae cholini transportantis investigatum est.Concludimus CCTα et laminas specialiter cooperari ad formandum NR, sed altiore structura involucri nuclei minimam ictum in actione CCT ac PC synthesin habet.
