5-Nitro-1,10-phænanthrolineum CAS:4199-88-6 Lumen luteum vel cristallum brunneum
| Catalogue Number | XD90385 |
| Product Name | 5-Nitro-1,10-phenanthroline |
| CAS | 4199-88-6 |
| Formulae hypotheticae | C12H7N3O2 |
| M. Pondus | 225.21 |
Product Specification
| Liquescens punctum | 200 - 203 °C |
| Assay | 99% |
| Aspectus | Lumen flavo ad brunneis cristallum |
Quindecim platini (II) metallo-intercalatores innixi compositi sunt, qui uti substituuntur ligandi 1,10-phenanthrilinei, incluso 5-chloro-1, 10-phenanthrolino (5-Cl-phen), 5-methyl-1,10- phaenanthroline (5-CH3-phen), 5-amino-1,10-phenanthroline (5-NH2-phen), 5-nitro-1,10-phenanthroline (5-NO2-phen) et dipyrido[3,2-d. :2',3'-f] quinoxaline (dpq), et achiralum ethylenediaminum (R, R-dach) et ligamentum chirurgicum 1S,2S-diaminocyclohexanum (S,S-dach) et 1R,2R-diaminocyclohexanum (R, R-dach) .Eorum cytotoxicitas in L1210 leukemia murina linea cellularum inhibitionis incrementi usus decrevit pertentare.Complexus metallicus maxime cytotoxici eae sunt quae ligamenta ancillis S,S-dach et 5-CH3-phenis ligandis intercalatis continent.Unus metallointercalator [Pt(5-CH3-phen)(S,S-dach)]Cl2(5MESS), 5-10 triplicem augmentum cytotoxicitatis ostendit cum agente cisplatino clinico comparato.Ex DNA experimentis ligandis nullam notabilem differentiam inter quoslibet complexorum metallorum apparet, significans nec DNA affinitatem ligandi nec modum ligandi/DNA adducendi formatum unicum esse determinatum cytotoxicitatis huius familiae platini (II) fundatum. metallointercalators.
