Glycosidasi glycosidasi inhibitoris validaminis, (1R*,2S,3S,4S,5S,6S*) -5-amino-1-(hydroxymethyl) bicycli[4.1.0] heptane. -2,3,4-triol, in 13 gradibus ex 2,3,4,6-tetra-O-benzyl-D-galactoso inserta sunt.Actiones inhibitoriae duorum amminum conformationaliter restrictarum, earumque acetamides respondentium, contra enzymes alpha-galactosidas mercatorum ex faba capulus et E. coll.Actio glycosyl hydrolasii familiae GH27 enzyme (fabae capulus) certatim ab 1R,6S-amine (7) inhibita erat, commercium ligatorium, quod per K(i) valorem microM 0,541 denotatum erat.Coli alpha-galactosidase exhibuit multo debiliorem commercium cum 1R,6S-amine (IC(50)= 80 microM).Diastereomericae 1S,6R-amine (9) ambas galactosidas debile adstringitur, (faba, IC(50)= 286 microM) et (E. coli, IC(50)= 2.46 mM).
